Clinical characteristics and treatment of infective endocarditis in children
10.3969/j.issn.1000-3606.2015.06.014
- VernacularTitle:儿童感染性心内膜炎临床表现与治疗对策
- Author:
Lijuan LUO
;
Qing CAO
;
Yunfang ZHOU
;
Shuhua PAN
;
Xihua WANG
- Publication Type:Journal Article
- Keywords:
infective endocarditis;
clinical characteristics;
pathogen;
vancomycin
- From:
Journal of Clinical Pediatrics
2015;(6):558-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics, treatment and prognosis of infective endocarditis in children. Methords Clinical data from 83 patients of infective endocarditis admitted from 1998 to 2012 were retrospectively analyzed. Results In a total of 83 patients, there were 53 males and 30 females, and the average age was 6.8±4.6 years. The main clinical characteristics were fever (77.1%) and mild to moderate anemia (71.1%). The C-reaction protein (67.5%), erythrocyte sedimen-tation rate (60.2%), and white blood cell (47.0%) were elevated. Twenty (24.1%) patients had embolism. Blood culture was pos-itive in 56 (67.5%) cases with bacteria mainly being Gram-positive and Streptococcus and Staphylococcus accounted for 89.3%. Vancomycin and other sensitive antibiotics were effective. Neoplasm was detected in 68 cases (82%) by transthoracic echocar-diograerphy. Fifty-ifve (66.2%) patients underwent cardio surgery. Seven patients (8.4%) died. Conclusion In recent years, the distribution of pathogenic bacteria in infective endocarditis had changed. Streptococcus mitis and Staphylococcus aureus has become a major pathogens and need to be treated by vancomycin and other sensitive antibiotics. The detection rate of neoplasm is higher by echocardiography.
