Effect of Jia-jian-yi-yin decoction on endothelial dysfunction in ovariecto-mized female rats
10.3969/j.issn.1000-4718.2015.06.008
- VernacularTitle:加减一阴煎改善去势大鼠内皮功能紊乱
- Author:
Jingting XU
;
Yalin CAO
;
Wenhui ZHENG
;
Yaxing ZHANG
;
Ling WANG
;
Tinghuai WANG
- Publication Type:Journal Article
- Keywords:
Jia-jian-yi-yin decoction;
Estradiol valerate;
Endothelium-dependent dilation;
Endothelial lipase
- From:
Chinese Journal of Pathophysiology
2015;(6):1008-1013
- CountryChina
- Language:Chinese
-
Abstract:
[ ABSTRACT] AIM:To investigate the effect of Jia-jian-yi-yin decoction on endothelium-dysfunction in ovariecto-mized rats.METHODS:The ovariectomized rats were treated with Jia-jian-yi-yin decoction or turbid liquid of estradiol va-lerate for 8 weeks.The vascular ring tension was measured.Scanning electron microscopy and Western blotting were ap-plied to assess the function of endothelium-dependent dilation, aortic endothelial morphology and the expression of endothe-lial lipase.The pathologic sections were prepared to observe the effect of Jia-jian-yi-yin decoction on the uterus.RE-SULTS:In ovariectomized rats, the decrease in endothelium-dependent relaxation to acetylcholine ( ACh) was reversed to normal level, the endothelial morphology returned to normal without lipid accumulation and the endothelial lipase expression was decreased by Jia-jian-yi-yin decoction.Furthermore, no obvious change of the wet weight of uterine between the ovari-ectomized rats with or without Jia-jian-yi-yin decoction treatment was observed.CONCLUSION:Jia-jian-yi-yin decoction may have protective effects on endothelium-dependent vasodilation and aortic endothelial morphology in estrogen-deficient animals.
