The Effect of Mitomycin C in Endonasal Dacryocystorhinostomy.
- Author:
Yun Tae KIM
1
;
Wha Sun CHUNG
Author Information
1. Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Korea. chungwha@med.yu.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Endonasal dacryocystorhinostomy;
Mitomycin C;
Mucosal osteum
- MeSH:
Dacryocystorhinostomy*;
Follow-Up Studies;
Granuloma;
Humans;
Lacrimal Apparatus Diseases;
Mitomycin*;
Osteotomy
- From:Journal of the Korean Ophthalmological Society
2002;43(4):728-732
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of intraoperative 0.2 mg/ml mitomycin C application on the success of endonasal dacryocystorhinostomy. METHODS: One hundred patients (121 eyes) were randomly divided into two groups. Group A (50 patients, 59 eyes) was treated with 0.2 mg/ml mitomycin C application during endonasal dacryocystorhinostomy and group B (50 patients, 62 eyes) was operated without application of mitomycin C. In group A, mitomycin C soaked cotton swabs were applied to the osteotomy site for five minutes. The surgical success was defined as either symptom free from epiphora or good passage of syringing. RESULTS: After the follow-up period of 6~24 months (mean 10.2 months), average diameter of mucosal osteum measured 1.17+/-0.52 mm in group A and 1.00+/-0.61 mm in group B. Granuloma around mucosal osteum was noted in 20 eyes of group A and in 31 eyes of group B. Primary success rate was 93.2% in group A and 82.3% in group B. There was no significant difference in mucosal osteum size or success rate between the two groups. CONCLUSIONS: Adjunctive use of intraoperative mitomycin C may be useful to maintain larger osteotomy size and provide better success rate of endonasal dacryocystorhinostomy.
