The levels of TGF-β1 in hypertensive renal function impairment patients and its clinical value analysis

VernacularTitle:高血压肾功能损害患者血清中转化生长因子β1含量检测及其临床价值分析
Author: Gong WANG ; Hui YUN ; Xueping ZENG
Publication Type:Journal Article
Keywords: Hypertension; Renal function impairment; Transforming growth factor-β1; Endogenous creatinine clearance rate
From: China Medical Equipment 2015;(6):112-115
CountryChina
Language:Chinese
Abstract: Objective:To detect the levels of TGF-β1 in hypertensive renal function impairment patients and its clinical value. Methods: Primary hypertension patients with no target organs damage were enrolled in control group, primary hypertension patients with renal function stageⅠand stageⅡwere enrolled in renal function stageⅠgroup and stageⅡgroup. Serum TGF-β1 levels and renal function indices of three groups were compared. Results:There were no significant difference of serum creatinine and blood urea nitrogen of three groups(F=23.523, P<0.05);endogenous creatinine clearance rate of renal functionⅠandⅡgroups were lower than that of control group, TGF-β1 levels of renal functionⅠandⅡ groups were higher than of control group; TGF-β1 levels were negatively correlated with creatinine clearance rate. Conclusion:TGF-β1 level is an ideal index to reflect renal function for its level significantly changes in renal damage stageⅠ,Ⅱand has good correlation with Cin.