The clinical fibrinogen reference range of plasma established for normal parturient women in labor Hefei area
10.3969/j.issn.1673-4130.2015.12.042
- VernacularTitle:合肥地区正常临产孕妇纤维蛋白原参考值范围的初步建立
- Author:
Tongqing CHEN
- Publication Type:Journal Article
- Keywords:
reference interval;
fibrinogen;
parturient women
- From:
International Journal of Laboratory Medicine
2015;(12):1737-1738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish reference range of fibrinogen (FIB) for normal parturient women in labor in Hefei area and compare it with previous FIB reference .Methods FIB of plasma samples for normal parturient women in labor were determined by Sysmex CA7000 automated blood coagulation analyzer and supporting reagent .All the FIB results were statistically analyzed and the reference range of FIB for normal parturient women was established in our laboratory .Consistency checking was applied for the comparisonwithpreviousreferencefromNationalClinicalLaboratorySOP (2.00-4.00g/L)anddecidedbytheKappavalue.Re‐sults The single sample K‐S test showed that distribution of FIB results for samples was skewed (P=0 .001) .The present FIB reference(P2 .5 ~ P97 .5 ) investigated was 4 .15(2 .81 -5 .40 g/L) .Compared to the previous FIB reference ,after using present FIB reference interval the abnormal rate was reduced from 61 .36% (991/1 615) to 5 .02% (81/1 615) .Through the consistency test ,we figured out that Kappa=0 .015(<0 .40) ,U=2 .25 ,P<0 .05 and these two reference intervals were inconsistent in criteria jud‐ging .These results showed that two reference intervals had poor judgment standard of consistency ,the previous reference range was not suitable for normal parturient women in labor .Conclusion The previous FIB reference range was not suitable for normal partu‐rient women in labor and we should establish a new FIB reference range in order to improve the evaluation of the accuracy of the parturient women in labor individual risk .
