Current research of role of Hox genes in pathogenesis of equinus deformity

VernacularTitle:Hox基因在马蹄内翻足病因中的研究进展
Author: Fengsong LIU ; Qinliang HU ; Shixin DU
Publication Type:Journal Article
Keywords: genes,homeobox; equinus deformity; genetics,medical; review; HOTAIR
From: Tianjin Medical Journal 2015;(6):702-704
CountryChina
Language:Chinese
Abstract: Congenital clubfoot(CCF), which is also known as equines deformity, is a common congenital malformation that affect children′s life quality. However, its cause is still to be elucidated. Currently, polygenetic and environmental fac?tors are both believed to play important roles in CCF pathogenesis. Several genes including HOX, PITX1, NAT2, P63, DTDS and COL9A were shown to contribute to congenital clubfoot, but which is the most critical gene remains unclear. Several re?ports have revealed that Hox genes are closely related to the cause of CCF. Hox genes are regulators of body morphogenesis, and its mutation result in limbs and trunk deformity in human. Here, we systematically reviewed the latest literature that stud?ied the role of Hox genes in pathogenesis of Congenital clubfoot, with the prospect of laying a foundation for its future clinic treatment.