Preparation and Characterization of Long Circulating Liposomes Containing Total Saponins of Paris Polyphylla Smith
- VernacularTitle:重楼总皂苷长循环脂质体的制备与表征
- Author:
Xiaofei ZHANG
;
Qiuting GUO
;
Changli WANG
- Publication Type:Journal Article
- Keywords:
Total saponins of Paris Polyphylla Smith;
PEGylated liposomes;
Stability
- From:
China Pharmacist
2015;(6):907-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare and characterize the PEGylated liposomes containing total saponins of Paris Polyphylla. Meth-ods:Using the size, PDI, zeta potential and encapsulation efficiency of the liposomes as the indicators, the influencing factors in the preparation were optimized. The particle size, PDI and zeta potential were studied by a Malvern Zetasizer, the morphology was ob-served under a TEM, and the stability was studied as well. Results:The particle size, PDI, zeta potential and encapsulation efficiency of the PEGylated liposomes was (109. 4 ± 32. 7) nm, (0. 171 ± 0. 036), ( -36. 7 ± 4. 5) mV and (93. 5 ± 3. 2) %, respectively. The liposomes were small spheres with smooth surface under the TEM. The long term stability studies showed that the liposomes were stable in 3 months after stored at 4℃. Conclusion:The preparation technology of the PEGylated liposomes containing total saponins of Paris Polyphylla is feasible, which can obtain liposomal preparations with high entrapment efficiency and good stability.
