Meta analysis on effect of parathyroid hormone elimination through hemoperfusion and hemodiafiltration
10.11958/j.issn.0253-9896.2015.06.029
- VernacularTitle:血液灌流和血液透析滤过对甲状旁腺素清除效果的Meta分析
- Author:
Zhe WANG
;
Fang WEI
;
Haiyan CHEN
;
Aili JIANG
- Publication Type:Journal Article
- Keywords:
parathyroid hormone;
renal dialysis;
hemofiltration;
Meta-analysis;
end-stage renal disease
- From:
Tianjin Medical Journal
2015;(6):684-689
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of hemoperfusion (HP) and hemodiafiltration (HDF) on elimination of para?thyroid hormone (PTH) from plasma in long-term hemodialysis patients.Methods MEDLINE (1966—2013.8), Embase (1974—2013.8), Chinese Wanfang database (1996—2013.8),CNKI(1979—2013.8)and the clinical control test database of Cochrane Library were searched. Published reports, unpublished studies and abstract from conference were retrieved manu?ally, all of which include studies of effect of PTH elimination through hemoperfusion and hemodiafiltration. Quality assess?ment and data mining were conducted by two independent investigators who performed meta-analysis using RevMan 5.2. Re?sults A total of 12 reports (400 patients) met the inclusion criteria and were included in this study. The meta-analysis showed that the elimination rate of PTH in long term hemodialysis patients was similar between using hemoperfusion and us?ing hemodiafiltration(WMD=-0.34,95%CI:-12.66-11.98,P=0.96). What’s more the elimination rate ofβ2-MG were also similar(WMD=-2.92,95%CI:-16.64-10.8,P=0.68)between those two treatments. However,The remission rate of pruritus was higher in patients using HP group than in HDF group(RR=1.33,95%CI:1.08-1.62,P=0.006). Conclusion HP and HDF can effectively clear PTH in chronic hemodialysis patients, but there was no statistically different between the two treat?ment methods.
