Effect of Drag-reducing Polymers on Coronary Microcirculation in Experimental Canine Model
10.3969/j.issn.1000-3614.2015.06.016
- VernacularTitle:减阻剂对犬冠状动脉微循环的影响
- Author:
Xianghui CHEN
;
Kai CUI
;
Feng HU
;
Daogang ZHA
;
Jiancheng XIU
;
Pingsheng WU
;
Yili LIU
- Publication Type:Journal Article
- Keywords:
Drag-reducing polymers;
Myocardial contrast echocardiography;
Myocardial microcirculation
- From:
Chinese Circulation Journal
2015;(6):573-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To test the feasibility of drag-reducing polymers (DRP) for improving coronary microcirculation in a canine model in order to provide the experimental basis for treating myocardial microcirculation dysfunction. Methods: A total of 8 dogs received open-chest surgery and they had intravenous injections, in turn, with adenosine (ADN), DRP 250 mg/L and DRP+ADN. The function y=A × (1-e-βt) was used to calculate the myocardium capillary volume (A value), capillary velocity (β value) and myocardial blood lfow (A ? β value) by myocardial contrast echocardiography. Results: With DRP infusion, the A value in experimental canine was similar to the baseline condition,P>0.05; while theβ value and A ? β value were signiifcantly increased as (0.57 ± 0.10) 1/s vs (0.23 ± 0.03) 1/s,P<0.01 and (11.51 ± 1.96) VI/s vs (5.15 ± 0.86) VI/s,P <0.05 respectively. With combined infusion of DRP+ADN, the β value and A ? β value were similar to the baseline condition, bothP>0.05. Conclusion: DRP improved coronary microcirculation primarily by modulating the β value in experimental canine model, and hopefully, this unique hemodynamics could provide a new approach for treating myocardial microcirculation dysfunction.
