MR Tracer Diffusion in Cerebral Interstitial Fluid of Elderly SD Rats
10.3969/j.issn.1005-5185.2015.06.003
- VernacularTitle:老年SD大鼠脑组织间液内MR示踪剂扩散特征的研究
- Author:
Shuaiwen WANG
;
Chunyan SHI
;
Long ZUO
;
Hongbin HAN
;
Junqiang LEI
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Extracellular space;
Interstitial fluid;
Contrast media;
Metabolic clearance rate;
Aging;
Models,animal;
Rats,Sprague-Dawley
- From:
Chinese Journal of Medical Imaging
2015;(6):409-412
- CountryChina
- Language:Chinese
-
Abstract:
Purpose With the progression of brain tissue aging, the transport and drainage characteristics of metabolites and secretory products for neurons in extracellular space occurs irreversible change. This paper aims to investigate and quantify MR tracer diffusion characteristics in cerebral interstitial fluid of elderly SD rats. Materials and Methods MR contrast agent Gd-DTPA was injected into the caudate nucleus of two groups of rats including 8 in experimental group (15-17 month old) and 15 in control group (7-10 month old). MR scan was performed at 0.25 h, 0.5 h, 1 h, 2 h, 3 h and 4 h to observe the dynamic distribution in the caudate and measure the diffusion and clearance rate. Results There was no statistically significant difference in diffusion rate and D* between control group with (3.32±0.70)×10-4 mm2/s and experimental group with (3.25±0.46)×10-4 mm2/s (t=1.739, P>0.05). The clearance rate k' was significantly different between control group (0.62±0.12)×10-4/s and experimental group (0.29±0.08)×10-4/s (t=11.602, P<0.05). Conclusion The degeneration of aging brain tissue changes the composition of extracellular space resulting in decreased speed of ISF clearance. This may cause accumulation of metabolites which eventually triggers a variety of age-related diseases.
