Estimation of Cystatin C as a Marker of Renal Function to Predict Serum Trough Concentrations of Vancomycin
10.3870/yydb.2015.06.007
- VernacularTitle:血清胱抑素C作为肾功能指标预测万古霉素谷浓度效能评估
- Author:
Yimei LIAO
;
Taotao LIU
;
Daohai CHENG
;
Hua LU
- Publication Type:Journal Article
- Keywords:
Cystatin C;
Serum creatinine;
Vancomycin;
Bayesian forecasting method
- From:
Herald of Medicine
2015;(6):730-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficiency of serum cystatin C as a marker of renal function to predict serum trough concentrations of vancomycin. Methods Data on trough concentrations of vancomycin(Cmea ),serum creatinine (Scr)concentrations,cystatin C( Cys C) concentrations were collected from 81 hospitalized patients who received vancomycin therapy. Predicted vancomycin trough concentrations(Cpre )were calculated based on Scr or Cys C concentrations associating with Bayesian forecasting method through NONMEM software. Finally,the correlations and distinctions between Cpre and Cmea were comparatively analyzed. Results There were both correlation between Cpre and Cmea in relation to Scr or Cys C(r = 0. 678,P<0. 01;r=0. 727,P<0. 01). Besides,the errors of mean predictive error(ME),mean absolute error(MAE)and root-mean-square error(RMSE)for Scr was - 5. 79,6. 86,9. 86 μg · mL-1 , respectively, where as the errors for Cys C was - 0. 82,5. 42, 7. 74 μg·mL-1 ,respectively. Conclusion Cystatin C is a good marker of renal function available for predicting serum vancomycin concentrations.
