Effect of Chitosan Gel on the Rectum Injury Induced by Acetic Acid in Rats
10.3870/yydb.2015.06.008
- VernacularTitle:壳聚糖凝胶对醋酸诱导大鼠直肠损伤的影响
- Author:
Xiaoping LI
;
Zonghai HUANG
;
Lichun HU
;
Caixia LOU
- Publication Type:Journal Article
- Keywords:
Chitosan gel;
Injury,rectum;
Acetic acid
- From:
Herald of Medicine
2015;(6):733-736
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the effect of chitosan gel on rectal injury which was induced by acetic acid. Methods 36 rats were anesthetized, 4% acetic acid swab was placed into the rectum (3 cm in depth for 1 min) to establish rectum injury model. These rats were divided into model control group, positive control group and drug group with 12 rats each group randomly. Chitosan gel was given to the drug group through anus with the dose of 1 575 mg·kg-1 , and hemorrhoid cream (1 575 mg·kg-1 ) was administered in the positive control group for 6 successive days. At 30 min, 1, 4, 6 day( s) after administration, 3 rats of each group were sacrificed, and were dissected, rectal injury and rectal pathology morphology changing of each group at different time points of administration were compared through visual observation. Results At 30 min, 1, 4, and 6 day(s) after administrating chitosan gel, score of rectum mucosa injury in dury group was lower than those in model control and positive control group. Pathological changes ( including epithelial tissue necrosis, mesenchyme hyperemia, hemorrhage, edema, gland injury, infiltration of inflammatory cells) were significantly slighter in drug group than in model control group and positive control group. Those lesions were restored faster in drug group than in model control group and positive control group, and there was no obvious scar. Conclusion Chitosan gel can obviously alleviate the rectal injury caused by 4% acetic acid and has therapeutic effect.
