Drug Loading and Release of Titanium Dioxide Nanoparticles with Near-infrared Light
10.3870/yydb.2015.06.025
- VernacularTitle:具有近红外荧光的二氧化钛纳米粒的载药与体外释放
- Author:
Jingyan YING
;
Airen XU
;
Jianhui RONG
;
Weicheng MA
;
Wenyue HE
- Publication Type:Journal Article
- Keywords:
Titanium dioxide (TiO2 );
Drug carrier;
Release,pH sensitivity;
Near-infrared light
- From:
Herald of Medicine
2015;(6):795-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare titanium dioxide (TiO2 ) nanoparticles with good near-infrared light and study the loading and release of doxorubicin. Methods The Sm doped TiO2 nanoparticles (Sm-TiO2 ) were synthesized using a modified solvothermal reaction and then observed with transmission electron microscope. The fluorescence spectrum, doxorubicin loading capacity and release profile were also determined. Results The obtained Sm-TiO2 nanoparticles with the length from 100-200 nm were fusiform and well dispersed. The emission wavelength was 640-670 nm. The drug loading capacity in water was 11. 5% . DOX in vitro was pH sensitive to release. Conclusion Sm-TiO2 nanoparticles have good near-infrared light, high drug loading capacity and controllable drug release are obtained and should be studied further more as a novel carrier.
