Study on experimental autoimmune encephalomyelitis with oxymatrine on rats model
- VernacularTitle:苦参素对大鼠实验性自身免疫性脑脊髓炎的研究
- Author:
Xiaoling LIU
;
Wenyan LI
;
Tian GAO
;
Xiaobin GUO
;
Yujuan DU
;
Yunfeng XIAO
- Publication Type:Journal Article
- Keywords:
oxymatrine;
experimental autoimmune encephalomyelitis;
pathology;
multiple sclerosis
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish experimental autoimmune cerebral spinal cord inflammation ( EAE) model rats, and observe the pathological changes and effect of oxymatrine on EAE model.Methods 30 rats were randomly divided into control group,EAE ( model group) group and oxymatrine group.The EAE symptom score was used to evaluate the rats after the model, and to observe the changes of its behavior.By HE staining and Kluver &Barrera myelin dyeing to observe the inflammation of the brain and spinal cord demyelinating changes.Results The animals in control group had no change in behavior and pathological.In model group, all animals occured behavioral changes, accompanied by varying degrees of demyelination and inflammatory infiltration of the brain and spinal cord.In oxymatrine group,6 rats did not appear EAE clinical manifestations and behavioral change, and the myelin structure was intact.Conclusion Oxymatrine can extend the incubation period experimental autoimmune encephalomyelitis in rats of the disease, relieve symptoms and protect nerve.
