Clinical investigation on distant metastases of salivary gland carcinoma after being treated by surgery combined with 125 I internal brachytherapy
10.3969/j.issn.1671-167X.2015.03.025
- VernacularTitle:经手术联合125 I粒子治疗唾液腺癌远处转移规律的探讨
- Author:
Wei WANG
;
Lei ZHENG
;
Shuming LIU
;
Mingwei HUANG
;
Yan SHI
;
Xiaoming LV
;
Jie ZHANG
;
Jianguo ZHANG
- Publication Type:Journal Article
- Keywords:
Salivary gland neoplasms;
Neoplasm metastasis;
Brachytherapy;
Iodine radioisotopes
- From:
Journal of Peking University(Health Sciences)
2015;(3):504-508
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate clinical features of distant metastases ( DM ) and analyze clinico-pathologic risk factors associated with DM from salivary gland carcinomas after being treated by surgery combined with 125 I internal brachytherapy. Methods: Between October 2001 and March 2010, 197 pa-tients with salivary gland carcinoma were treated by surgery combined with 125 I internal brachytherapy and had follow-up for 2 years or more. Univariate and multivariate analyses were performed to evaluate clini-copathologic risk factors that might influence the risk of distant metastases. Results:DM occurred in 28 of 197 patients (14. 2%). The commonest site of distant metastases overall was the lung 89. 3% (25/28), followed by bones 17. 9% (5/28) and liver (4/28). DM developed after an average interval of (44. 2 ± 45. 8) months from the time of initial diagnosis, and the mean interval was 64 months. The average time to death after the diagnosis of DM was only (9. 7 ± 13. 4) months, and the mean time was 12 months. The 3-year locoregional control rate and survival rate were 90. 8%, and 87. 8% respectively,and the 5-year ones 84. 0% and 81. 0%, respectively. Univariate analyses revealed that the risk of distant metasta-ses was significantly influenced by locoregional tumor failure (F=26. 997,P<0. 01) and histologic dif-ferentiation (F=1. 592,P<0. 01). Multivariate analysis of freedom from distant metastases revealed that locoregional control (F=29. 332,P<0. 01) significantly influenced this end point. Conclusion: Sali-vary gland carcinoma could achieve high local control rate after being treated by surgery combined with 125 I internal brachytherapy, and the average interval from diagnosis to DM was prolonged, DM was signifi-cantly influenced bylocoregional control.
