Analysis on clinical characteristics of 10 patients with granulocytic sarcoma

VernacularTitle:粒细胞肉瘤十例临床特点分析
Author: Dongping HUANG ; Xinghong WANG ; Guiping SU
Publication Type:Journal Article
Keywords: Sarcoma,myeloid; Diagnosis; Therapy; Prognosis
From: Journal of Leukemia & Lymphoma 2013;22(4):233-235
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical characteristics,diagnosis,therapy and prognostic features of granulocytic sarcoma (GS).Methods Retrospective analysis was used to analyse 10 cases who were diagnosed with GS.Results Five patients were diagnosed with primary GS.GS was accompanied by APL in one case,CML in 3 cases and MDS in one case.Patients were treated with resection and chemotherapy,or imatinib treatment.Follow-up data were available from 9 patients,with 2 patients being still alive.The survival of one patient who received high-dose cytarabine chemotherapy was 66 months.The other 7patients died of tumor-related diseases,and their survival ranged from 4 to 17 months.Conclusion GS is a rarely diagnosed disease.A correct diagnosis of GS depends on detailed morphological examination and immunohistochemical study.The clinical outcome of patients is poor,and AML-type chemotherapy is the proper treatment for GS.High-intensity chemotherapy and hematopoietic stem cell transplantation might improve long-term survival.