Diagnostic value of 18F-FDG PET-CT in lymphoma associated hemophagocytic syndrome
10.3760/cma.j.issn.1009-9921.2013.04.005
- VernacularTitle:18F-FDG PET-CT在诊断淋巴瘤相关噬血细胞综合征中的应用
- Author:
Shuo LI
;
Zhao WANG
;
Yini WANG
;
Jia ZHANG
;
Lijuan YAN
;
Qing WEI
;
Ran TANG
- Publication Type:Journal Article
- Keywords:
18F-FDG PET-CT;
Lymphoma;
Hemophagocytic syndrome
- From:
Journal of Leukemia & Lymphoma
2013;22(4):209-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of 18F-FDG PET-CT in lymphoma associated hemophagocytic syndrome (HSP).Methods Retrospective analysis of 30 patients with HPS who underwent 18F-FDG PET-CT detection,and was also compared to pathologically confirmed lymphoma associated HPS to evaluate its diagnostic sensitivity,specificity,positive predictive value and negative predictive value,and to analyze the characteristics of PET-CT imaging in lymphoma associated HPS.Results In the 30 patients,the sensitivity,specificity,positive predictive value and negative predictive value in detecting lymphoma associated HPS by 18F-FDG PET-CT were 85.71％ (12/14),93.75 ％ (15/16),92.31％ (12/13) and 88.24 ％(15/17),respectively.The sensitivities of PET-CT between T-cell and B-cell lymphoma related HPS had no significant difference (P =0.066).In superficial lymph nodes,supraclavicular lymph nodes were the most commonly involved.In deeper tissues and organs,spleen was the most commonly involved site,followed by liver,abdominal retroperitoneal lymph nodes and bone marrow.Conclusion 18F-FDG PET-CT has a high sensitivity and specificity in the detection of lymphoma associated HPS,and may provide valuable information for diagnosis and treatment.
