Investigation of relationship between schizophrenia and ten kinds of elements in serum
- VernacularTitle:探讨精神分裂症与血清中10种元素的关系
- Author:
Lailai YAN
;
Chao LV
;
Jinyun QIU
;
Yaqiong LIU
;
Jingyu WANG
- Publication Type:Journal Article
- Keywords:
schizophrenia;
inductively coupled plasma mass spectrometer;
element
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the changes of ten elemental contents in serum and schizophrenia.Methods Calcium (Ca), magnesium (Mg), zinc (Zn), iron (Fe), aluminum (Al), arsenic (As), selenium (Se), copper (Cu), lead (Pb), manganese (Mn) in serum in the of schizophrenic patients and normal subjects are measured by inductively coupled plasma mass spectrometer and inductively coupled plasma emission spectrometer, compared the content of elements between the schizophrenia and normal.Results There were significant differences ( P<0.05) in other elements between two groups except lead.The contents of Ca,Fe,Mg,Zn,As,Se,Cu in the patients with schizophrenia were significantly lower than those in control, while Al, Mn were significantly higher than those in control.Most of elements in serum between case and control groups were correlated (P<0.05).Some of element ratios which have physiological significance were significant statistically (P<0.05), such as: Ca/Mg, Ca/Fe and so on.Conclusion These findings suggest that the patients with schizophrenia might have an abnormal elemental metabolism.Given the relationship among the elements, the element ratios are more valuable in reflecting the relationship between schizophrenia and elements.
