Effect of boningmycin on expression of capsid protein L1 and serum immune factors in cervical HPV infection patients
- VernacularTitle:博宁霉素对宫颈人乳头瘤病毒感染患者L1壳蛋白表达及血清免疫因子水平的影响
- Author:
Mengqi HUANG
;
Aizeng CHEN
;
Wenjing CAI
- Publication Type:Journal Article
- Keywords:
boningmycin;
human papillomavirus;
capsid protein L1;
immune function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of boningmycin on expression of capsid protein L1 and serum immune factors in cervical HPV infection patients.Methods 60 patients with cervical HPV infection were divided into experimental group and control group, 30 cases in each group.The control group were given recombinant human interferon α2b suppository, 100 000 IU, once every other day, and the experiment group were given boningmycin 300 mg intramuscular injection,once every other day.Treatment of 10 times for a course,2 consecutive courses After treatment, the HPV capsid protein L1, serum TNF-α, IL-2, IFN-αand HPV were compared.Results Compared with control group after treatment, the percentage of HPV capsid protein L1 increased ( P <0.05 ) , serum TNF-α, IFN-αlevels increased ( P <0.05 ) , IL-2 decreased ( P <0.05 ) , and HPV positive rate decreased( P <0.05 ).Conclusion Boningmycin could reduce the percentage of capsid protein L1 in patients with cervical human papilloma virus infection, elevate serum TNF-αand IFN-αlevels, reduce the level of IL-2 and HPV positive rate.
