Effect of parecoxib on sufentanil dosage and its analgesic effect in patients with laparoscopic radical resection of rectal carcinoma under combined anesthesia
- VernacularTitle:帕瑞昔布对复合麻醉下行腹腔镜直肠癌根治术患者舒芬太尼用药量的影响及其镇痛效果
- Author:
Yang LIU
;
Pingxuan GUO
;
Sheng WANG
;
Tai WANG
;
Qingbo HAN
;
Zhenhua WANG
- Publication Type:Journal Article
- Keywords:
parecoxib;
sufentanil;
laparoscopic radical resection of rectal cancer;
analgesic effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of parecoxib on sufentanil dosage and its analgesic effect in patients with laparoscopic radical resection of rectal carcinoma under combined anesthesia.Methods 120 cases patients diagnosed with rectal cancer and prepared to laparoscopic radical resection of rectal cancer were selected in Kailuan General Hospital, and randomly divided into experimental group and control group, 60 cases in each group, experimental group induced anesthesia with 40mg parecoxib sodium intravenous injection, while the control group were treated with normal saline, the postoperative dosage of sufentanil, analgesia pump using frequency and other indicators were detected at 6,12,24 and 48 h, and analgesic effect were observed.Results Compared with control group, in experimental group, postoperative dosage of sufentanil was less ( P <0.05 ) , analgesia pump pressing times and effective pressing numbers were fewer (P<0.05), VAS pain score was lower (P<0.05) and Ramsay score was lower (P<0.05) at each time point.Conclusion Parecoxib could reduce the dosage of sufentanil after laparoscopic radical resection of rectal cancer, and enhance the analgesic effect.
