Relationship between microRNA-200c and ZEB1 of epithelial mesenchymal transition factor in cervical cancer
- VernacularTitle:宫颈癌上皮间质转化相关因子ZEB1与microRNA-200 c的关系
- Author:
Yaling TANG
;
Jing RAN
;
Yan ZHAO
- Publication Type:Journal Article
- Keywords:
cervical cancer;
ZEB1;
microRNA-200c;
tumor markers
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):95-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relationship between microRNA-200c and ZEB1 in cervical epithelial mesenchymal transition factor. Methods 50 cases diagnosed with cervical cancer whose tumor tissue were taken to be the experiment group.50 cases diagnosed with uterine myoma whose normal tissue were taken to be the control group.ZEB1 and microRNA-200c of uterine tissue were were detected.Results The average level of ZEB1 in the experimental group was significantly higher than that of the control group (P<0.05), and in cervical cancer, lymph node metastasis and the depth of myometrial invasion had statistically significant (P<0.05).In experimental group, microRNA-200c average was lower than control group (P<0.05), and in cervical cancer, different pathological grade group, lymph node metastasis and deep muscular layer infiltration had statistically significant(P<0.05).In experimental group, ZEB1 and microRNA-200c showed negative correlation(r =-0.270 P =0.001).Conclusion The expression level of ZEB1 in cervical cancer is higher, and the expression level of microRNA-200c in cervical cancer is lower, suggesting that the two factors may play an important role in the invasion and metastasis of cervical cancer.The correlation between the two factors suggests that microRNA-200c may be involved in the process of cervical cancer by ZEB1.
