IgM nephropathy with nephrotic syndrome in children
10.3760/cma.j.issn.1673-4408.2015.03.027
- VernacularTitle:以肾病综合征为临床表现的儿童IgM肾病临床特征
- Author:
Zhihui LI
;
Ying WANG
;
Cuirong DUAN
;
Tianhui WU
;
Yunfeng DING
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
IgM nephropathy;
Renal pathology;
Steroid-resistant;
Mycophenolate mofetil;
Children
- From:
International Journal of Pediatrics
2015;42(3):334-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical charactors and treatment of IgM nephropathy with nephrotic syndrome(NS) in children.Methods Thirty-six IgM nephropathy patients hospitalized in Hunan Children's Hospital as research group(group A),from June 2005 to June 2012.One hundred and six patients with minimal change disease (MCD) as control group (group B),followed up for 1 ～ 8 years.Results (1) Hematuria at presentation of the two groups respectly 3.8％ vs 30.6％ (x2 =20.403,P ＜ 0.05).(2) Renal pathology revealed that there were 26 (72.2％)patients with minimal change disease,9 cases (72.2 ％)with moderate membranoproliferative glomerulonephritis,1 cases with focal segmental glomerulosclerosis.(3) According to renal pathology,group A patients were divided into two sub groups:mild group and moderate group.To compared with group B,the steroid-resistant incidence of the 3 group were respectly 12.3％,19.2％,77.8％ (x2 =24.369,P ＜ 0.05).There was no significant difference between control group and mild group.(4)The remission rate of proteinuria in steroid-resistant patients who combined to use mycophenolate mofetil (MMF) with the two groups were respectively 50％ and 85.7 ％ (x2 =3.60,P ＞ 0.05).Conclusion Incidence of hematuria is higher in IgM nephropathy patients and patients with renal pathology for moderate lesions have a high steroid-resistant,and need use immunosuppressive early.MMF may be a good immunosuppressive for theses patients.
