Effect of berberine on D-dimer, fibrinogen and interleukin-6 in peripheral blood of ovarian cancer patients
- VernacularTitle:小檗碱对卵巢癌患者外周血D-二聚体、FIB与IL-6变化的研究
- Author:
Lingye FAN
;
Lei SHI
;
Chunyan WANG
;
Ping ZHAN
;
Qianchuan REN
- Publication Type:Journal Article
- Keywords:
ovarian carcinoma;
berberine;
D-dimer;
fibrinogen;
interleukin-6
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of berberine on D-dimer, fibrinogen (FIB) and interleukin-6(IL-6) in peripheral blood of ovarian cancer patients.Methods 130 cases selected from the hospital were diagnosed as unilateral ovarian cancer, treated by surgery and chemotherapy.The patients were divided into control group (25 cases) and experimental group (105 cases), and the experimental group were randomly divided into A, B, C three groups, 35 cases in each group.The experimental group received berberine hydrochloride tablets, orally, three times a day, on the basis of conventional chemotherapy.The experimental groups were divided into three subgroups according to the dosage: A group: 0.3 g, B group: 0.2 g, C group:0.1 g, 35 cases in each group, continuously treated for 2 weeks.The levels of D-dimer, FIB and IL-6 and quality of life score were detected before and after treatment.Results After treatment, D-dimer level in each subgroup of experimental group was lower than that in control group, respectively, and A group
