Roles of vascular endothelial growth factor and insulin-like growth factor-1 in retinopathy of prematurity
10.3760/cma.j.issn.1673-4408.2014.06.005
- VernacularTitle:血管内皮生长因子及胰岛素样生长因子-1在早产儿视网膜病变中的作用
- Author:
Yongliang HAN
- Publication Type:Journal Article
- Keywords:
Retinopathy of prematurity;
Vascular endothelial growth factor;
Insulin-like growth factor-1;
Pathogenesis
- From:
International Journal of Pediatrics
2014;41(6):590-593
- CountryChina
- Language:Chinese
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Abstract:
Retinopathy of prematurity (ROP)occurs in the premature infant especially very low birth weight infants.It is an important reason which cause vision loss in children.The main pathological feature of ROP is retinal neovascularization.Vascular endothelial growth factor (VEGF) and insulin-like growth factor-1 (IGF-1) play a vital role in neovascularization by controlling the proliferation of vascular endothelial cells.In recent years many clinical studies have shown that intravitreal injection of anti-VEGF and increasing serum IGF-1 level of premature infants in early time is an effective method to prevent ROP.This article,according to the background of domestic and foreign relevant researches,reviews roles of VEGF and IGF-1 in ROP.
