Comparison of effect between duloxetine combined with small-dose of mirtazapine and duloxetine in treatment of refractory depression in elder patients
- VernacularTitle:度洛西汀合并小剂量米氮平与单用度洛西汀治疗老年期难治性抑郁症的对比研究
- Author:
Hui SUN
;
Yanhui LIU
;
Jiwei WANG
;
Xinhong TENG
- Publication Type:Journal Article
- Keywords:
duloxetine;
mirtazapine;
refractory depression;
clinical effect;
security
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare effect and security between duloxetine combined with small-dose of mirtazapine and duloxetine alone in treatment of refractory depression in elder patients.Methods A total of 100 cases elder refractory depression patients were randamly divided into study group (duloxetine+mirtazapine, 50 cases) and control group(duloxetine, 50 cases).Compared HAMD,HAMA and CGI-SI between two groups, as well as the side reactions and TESS.Regression analysed mirtazapine blood concentration and HAMD subtraction rate.Results The effective rate of study group was 92.00%, while in control group was 76.00%, the difference was statistically significant(P<0.05).After treatment, the HAMD, HAMA and CGI-SI of each group significantly increased, and the difference of HAMD, HAMA and CGI-SI at 2w, 4w and 8w between two groups were statistically significant(P<0.05).The TESS and side reaction of two groups had no statistical difference.Conclusion Effect of duloxetine combined with small-dose of mirtazapine in treatment of refractory depression is better than duloxetine alone use, without significant side reaction.
