Study on compatibility of vidarabine monophosphate for injection and aciclovir injection
- VernacularTitle:注射用单磷酸阿糖腺苷与阿昔洛韦注射液的配伍研究
- Author:
Xiaojun XIA
;
Yingchun ZHANG
;
Junli JING
;
Chunyan WEI
- Publication Type:Journal Article
- Keywords:
vidarabine monophosphate for injection;
aciclovir injection;
orthogonal test;
optimize compatible
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):143-146
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study optimal compatibility scheme of vidarabine monophosphate for injection combined with aciclovir injection. Methods L18(35) of orthogonal design was used with five factors: temperature, illumination,storage time,solvent and solvent dosage;the insoluble particles were observed by GWJ-4 type particle analyzer.The content of vidarabine monophosphate and aciclovir was detected by HPLC.Optimization of the best scheme of vidarabine monophosphate for Injection combined with aciclovir injection was studied.Results The regression equation of vidarabine monophosphate and aciclovir were A=3.78 ×104C+2.32, r=0.9997(n=5)and A=7.11 ×105C-4.65, r=0.9995(n=5),The results showed that the relationship between the range of 200-900μg/mL(vidarabine monophosphate) and the range of 1000-4500μg/mL(aciclovir) was good.The optimal compatibility conditions are the follows:temperature of 25,as far as possible away from light;Vidarabine monophosphate for injection 1 (0.1 g/branch) and 1 acyclovir injection (10 mL:0.5 g) mixed with 100 mL 0.9% sodium chloride injection,and dropping out within 4 h after compatibility. Conclusion The optimal compatibility scheme has good repeatability,injection solution stability is good.It prouides scientific reference for the safty of clinical rational drug use.
