Recent advance of small molecular VEGFR-2 inhibitors for cancer treatment
- VernacularTitle:小分子血管内皮生长因子受体抑制剂的抗肿瘤研究进展
- Author:
Ziyu GUO
;
Zhaopeng LIU
- Publication Type:Journal Article
- Keywords:
anticancer;
angiogenesis;
inhibitors;
VEGF;
VEGFR;
VEGFR-2
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):176-180
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor receptors ( VEGFR ) belong to the receptor-type tyrosine kinase ( RTK ) super family and play important roles in tumor angiogenesis.Abnormal activation of VEGFR results in several disorders including cancer.VEGFR-2 is the major signal transducer for angiogenesis, and therefore, it becomes a good target for the inhibition of tumor development and metastasis.Nowadays, the VEGFR-based antiangiogenic therapy becomes one of the most powerful clinical strategies for cancer treatment.In this review, small molecular VEGFR-2 inhibitors are classified according to their structural features, their biological activities and current statue are briefly introduced.
