Clinical significance of N-terminal pro-brain natriuretic peptide and D-dimer in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4904.2015.04.011
- VernacularTitle:氨基末端脑钠肽前体和D-二聚体在慢性阻塞性肺疾病患者中检测的临床意义
- Author:
Guofeng ZHENG
;
Jun ZHANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
N-terminal pro-brain natriuretic peptide;
D-dimer
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(4):273-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and plasma D-dimer (D-D) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and stable chronic obstructive pulmonary disease (COPD).Methods The clinical data of 76 patients with AECOPD (AECOPD group) and 68 patients with stable COPD (stable COPD group) were analyzed retrospectively.Serum NT-proBNP,plasma D-D levels and arterial blood gas analysis were measured and compared.Results The levels of serum NT-proBNP and plasma D-D in AECOPD group were (918 ± 271) ng/L and (0.269 ±0.048) mg/L,in stable COPD group were (264 ± 32) ng/L and (0.223 ± 0.042) mg/L.The levels of serum NT-proBNP and plasma D-D in AECOPD group were significantly higher than those in stable COPD group (P ＜ 0.01).The levels of serum NT-proBNP and plasma D-D were negatively correlated with arterial blood oxygen partial pressure (r =-0.181,P =0.030;r =-0.166,P =0.047),and were positively correlated with arterial blood carbon dioxide partial pressure (r =0.763,P ＜ 0.01;r =0.424,P ＜ 0.01).Conclusion Combined detection of serum NT-proBNP and plasma D-D has important clinical significance in evaluating severity of COPD,and may indicate AECOPD.
