Expression and significance of PTEN and Ki-67 in thymoma
10.3760/cma.j.issn.1673-4904.2014.29.004
- VernacularTitle:PTEN和Ki-67在胸腺瘤中表达及意义
- Author:
Shiyun FENG
;
Yao ZHANG
;
Youbin CUI
- Publication Type:Journal Article
- Keywords:
Thymoma;
PTEN;
Ki-67
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(29):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of PTEN,Ki-67,type of credits of thymoma in WHO organization and Masaoka staging,and the significance of the biology's expression in thymoma.Methods The expression of PTEN and Ki-67 in 52 pieces of thymoma specimens was detected by the method of immunohistochemical SP.Results Positive expression rate of the 52 patients with thymoma was decreased gradually after WHO classification (8/10,10/14,6/12,4/11,0,0 and 10/13,12/20,6/16,0),Masaoka staging and PTEN.The difference were significant in statistics (λ2 =11.751,P =0.038 ; x2 =8.311,P =0.040).Positive expression rate of Ki-67 was gradually increased (1/10,6/14,6/12,8/11,2/3,2/2 and 3/13,9/20,10/16,3/3),the difference was also significant in statistics (x2 =11.231,P =0.047; x2 =7.904,P =0.048).Conclusions The positive expression rate of PTEN,Ki-67 are both related to clinical classification and staging closely.The detection to the positive expression rate of PTEN and Ki-67 can contribute to judging thymoma biological characteristics,thus,it will be helpful in diagnosing the thymoma,analyzing the degree of malignancy,invading and transferring ability.And then provide objective indicators for clinical diagnosis and treatment.
