Study on the correlation between oxidized low density lipoprotein and soluble P-selectin and carotid atherosclerosis in metabolic syndrome patients and carotid atherosclerosis
10.3760/cma.j.issn.1673-4904.2014.28.017
- VernacularTitle:代谢综合征患者可溶性P-选择素、氧化型低密度脂蛋白与颈动脉粥样硬化的相关性
- Author:
Libin YANG
;
Yingjie MENG
;
Yan ZHANG
;
Wangsheng SUO
;
Xiaoqian LI
- Publication Type:Journal Article
- Keywords:
Soluble P-selectin;
Oxidized low density lipoprotein;
Metabolic syndrome X;
Carotid atherosclerosis
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(28):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship and clinical significance between the serum levels of oxidized low density lipoprotein (Ox-LDL) and soluble P-selectin (SP-S),and carotid atherosclerosis (CA) in metabolic syndrome (MS) patients.Methods In 103 cases of MS patients and 44 healthy subjects (control group),in MS patients with 3 MS diagnostic criteria for the low risk group (51 cases),with ≥ 4 MS diagnostic criteria for high risk group (52 cases).Carotid artery intima-media thickness (IMT) and plaque was measured by color Doppler ultrasound,serum Ox-LDL,SP-S was determined by enzyme linked immunosorbent assay,and pearson regression analysis of linear correlation and classification of two non condition Logistic was performed.Results The serum levels of Ox-LDL,SP-S,carotid artery IMT in low risk group and high risk group were higher than those in control group [(36.42 ±7.17) μg/L and (54.44± 8.10) μg/Lvs.(30.08±7.15) μg/L,(71.46± 12.52) μ g/Land (89.33±20.28) μg/Lvs.(49.95 ± 12.49) μ g/L,(0.86 ± 0.11) mm and (1.00 ± 0.10) mm vs.(0.69 ± 0.11) mm],the difference was statistically significant (P ＜ 0.01).The incidence of plaque in high-risk group and low-risk group was significantly higher than that in control group [55.8％ (29/52) and 45.1％ (23/51) vs.15.9％ (7/44)],the difference was statistically significant (P ＜ 0.01).Linear correlation analysis results of Pearson display,Ox-LDL was positively correlated with SP-S (P ＜0.01).Conclusion Serum Ox-LDL and SP-S are independent risk factor for carotid atherosclerosis in MS patients,they can evaluate progression of carotid atherosclerosis in patients with MS.
