Effect of butylphthalide on serum sex hormone,5-HT and sleep quality in patients with stroke sleep disorder
- VernacularTitle:丁苯酞对脑卒中睡眠障碍患者血清性激素、5-羟色胺及睡眠质量的影响
- Author:
Hanshui CHEN
;
Suijun TONG
;
Qilin MA
- Publication Type:Journal Article
- Keywords:
butylphthalide;
stroke sleep disorder;
sex hormone;
5-HT;
PSQI
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(6):52-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of butylphthalide on serum sex hormone,5-HT and sleep quality in patients with stroke sleep disorder. Methods 240 patients with stroke sleep disorder in our hospital were selected,according to clinical medication were divided into 2 groups.Control group (n=120) were treated by routine treatment, experimental group (n=120) was treated on the base of the control group with butylphthalide.Serum sex hormones, 5-HT and PSQI levels were detected after the treatment.Results Compared with the control group,LH, FSH levels of the experiment were higher(P<0.05),E2 level was lower(P<0.05),serum 5-TH level was higher(P<0.05),PSQI score was lower(P<0.05),the difference was statistically significant.Conclusion Butylphthalide can improve stroke sleep disorder serum sex hormone and 5-HT levels, improve sleep quality, has guiding significance for the treatment.
