Role of mitomycin C in interventional therapy for tuberculous cicatricial stenosis of the central airway
10.3969/j.issn.1006-5725.2015.11.034
- VernacularTitle:丝裂霉素C在介入治疗结核性中心气道瘢痕狭窄中的作用
- Author:
Qiong FANG
;
Minli ZHENG
;
Yingwen LI
;
Zhiming MA
;
Yikai XIE
;
Pinru CHEN
;
Chunmei TANG
;
Yanbin ZHANG
- Publication Type:Journal Article
- Keywords:
Airway cicatricial stenosis/tuberculosis;
Mitomycin C;
Bronchial balloon dilatation
- From:
The Journal of Practical Medicine
2015;(11):1829-1831
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of bronchoscopic MMC topical spraying for the treatment of tuberculous cicatricial stenosis of the central airway. Methods 45 patients with t tuberculous cicatricial stenosis of the central airway were randomly divided into a control group (14 patients), treatment group 1 (group1, 15 patients), or treatment group 2 (group 2, 16 patients), who received bronchial balloon dilatation alone, bronchial balloon dilatation combined with topical MMC spraying for one time, and for twice, respectively . The clinical efficacy was observed by using the MRC score and measuring airway diameter at the time points before treatment, end of treatment, and 3, 6, and 12 months after treatment, respectively. Results For the MRC scores at different time points, the MRC scores in group 2 (0.06 ± 0.25) and group 1 (0.33 ± 0.617) were significantly lower than those in the control group at 3 months after treatment (P < 0.05 for all comparisons);there were nosignificant differences at the other time points among the three groups. For the airway mean diameters at the different time points, the airway mean diameter was higher in group 2 than in the control group at 3 and 6 months after treatment (P < 0.01), and in group 1 at 3, 6, and 12 months (P < 0.05). No statistical differences were found in the other time points among three groups (P > 0.05). Conclusions Bronchial balloon dilatation combined with topical MMC spraying has certain short-term and long-term efficacy for improving dyspnea and maintaining the airway diameter after dilatation.
