The expressions of chemokine CXCL5 and its receptor CXCR2 in HCC and the significance in the prognostic evaluation
10.3969/j.issn.1006-5725.2015.12.011
- VernacularTitle:肝细胞癌中趋化因子CXCL5及其受体CXCR2的表达及意义
- Author:
Jiumei SHEN
;
Yuanhua CHENG
;
Qizhong ZHEN
;
Mengyi YU
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
CXCL5;
CXCR2;
MVD;
Immunohistochemistry
- From:
The Journal of Practical Medicine
2015;(12):1936-1939
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of chemokine CXCL5 and its receptor CXCR2 in hepatocellular carcinoma (HCC), investigate their relationships between CXCL5, CXCR2 and clinicopathologic features and probe into the significance in the evaluation of prognosis. Methods Immunohistochemical Envision method was utilized to detect the expressions of CXCL5 and CXCR2 in HCC , to explore their relationship between CXCL5, CXCR2 and clinicopathologic features and MVD in HCC. Results (1) The high expression rates of CXCL5 and CXCR2 protein was 64.7% and 68.6%, respectively, significantly higher than those in adjacent tissues of HCC(17.6%, 15.7%, P < 0.05). The overexpression of CXCL5 protein had correlation with tumor size, differentiation, TNM stage and vascular invasion (P < 0.05) and the overexpression of CXCR2 protein did with tumor grade and vascular invasion (P < 0.05). (2) The value of MVD was higher in HCC than that in the adjacent tissues of HCC (P < 0.05), and had positive correlation with the expressions of CXCL5, and CXCR2 proteins. (3) The higher rates of recurrence and metastasis were in the groups of higher expression of CXCL5 and CXCR2 proteins (P < 0.05). Conclusions The overexpressions of CXCL5 and CXCR2 may promote the occurrence and development of HCC as well as the neovasculation in HCC. Therefore, they can be used as markers to evaluate the prognosis of HCC.
