Fluvoxoxamine combined with oxycodone hydrochloride controlled-release tablets in treatment of moderate and severe cancer pain
10.3969/j.issn.1006-5725.2015.12.038
- VernacularTitle:氟伏沙明联合羟考酮缓释片治疗中重度癌痛
- Author:
Jun LIU
;
Yang XIAO
;
Yimin MA
;
Juan CHANG
;
Wei WEI
;
Xiaohong HUANG
;
Yijia WU
;
Jianxiong GUO
;
Bo YU
- Publication Type:Journal Article
- Keywords:
Cancer pain;
Fluvoxoxamine;
Oxycodone hydrochloride controlled-release tablets;
Efficacy;
Adverse reaction
- From:
The Journal of Practical Medicine
2015;(12):2014-2017
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe clinical efficacy and safety on the treatment of moderate-severe cancer pain by Fluvoxamine combined with Oxycodone. Methods 120 cancer patients with moderate pain and 120 cases with severe pain were selected, randomly divided into experimental group and control group. The control group were given oxycodone alone , and experimental group given fluvoxamine combined with oxycodone , till the pain relieved, then the degree of pain relief, oxycodone dosage, life quality and side effects were evaluated. Results The degree of pain relief in experimental group were much better than control group (P < 0.05). Oxycodone consumption were lower in experimental group than control group , and the difference was no significant difference in controlling moderate pain (P = 0.065), while statistically significant in controlling severe pain (P = 0.035). The general status, daily activity, mood, and sleep affected by cancer pain were released after treatment, especially in experimental group (P < 0.05). The most common side effects were approximative, and the incidence of constipation, nausea/vomiting, lethargy were lower in experimental group than control group (P =0.026). Conclusion Fluvoxamine combined with Oxycodone can effectively control moderate-severe cancer pain, and reduce the oxycodone dosage and some side effects, and therefore, improve the quality of life.
