Effect of two kinds of hemofiltration on vascular endothelial system
- VernacularTitle:两种血液滤过模式对血管内皮系统的影响
- Author:
Yuting WEI
;
Mi LI
;
Xingying LUO
;
Wenying ZHOU
;
Jianting KE
- Publication Type:Journal Article
- Keywords:
Continuous venovenous hemofiltration;
Hemodiafiltration;
Adhesion molecule;
von Wilebrand factor;
Matrix metalloproteinase-9
- From:
Journal of Chinese Physician
2015;(z1):28-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of single CVVH and HDF on endothelial system. Methods Group CVVH:20 patients with multiple organ dysfunction syndrome ( MODS) underwent CVVH for 12h.Vascular access was through two-lumen catheter in femoral vein;Group HDF:Twenty patients with end stage renal disease (ESRD) on maintenance hemodialysis underwent HDF for 4h.Vascular access was through internal arteriovenous fistula.Group control:Healthy people were examined at our hospital.The se-rum levels of sVCAM-1, sICAM-1, vWF and MMP-9 were measured by enzyme-linked immunosorbent assay ( ELISA) after centrifugation in treatment group before and after treatment.Four cytokines were also meas-ured in fasting healthy subjects in the morning.Results The levels of serum sVCAM-1, sICAM-1, vWF, MMP-9 were significantly higher in Group CVVH and HDF than control group before and after treatment( P<0.05).Group CVVH:The serum levels of sICAM-1 and sVCAM-1 were significantly lower in post-treat-ment than pre-treatment, But the serum levels of vWF and MMP-9 showed no obvious changes after CVVH;Group HDF:the levels of four cytokines showed no obvious changes after single HDF.Conclusions Endo-thelium becomes impaired in MODS and ESRD patients, Endothelium may be protected by CVVH through the partial removal of cytokines harmful to endothelium in MODS patients.Single HDF therapy does not pro-tect endothelial function obviously in MHD patients.
