The mechanism of intravenous lidocaine in alleviation of injection pains by intravenous propofol
10.3969/j.issn.1006-5725.2015.12.039
- VernacularTitle:静脉注射利多卡因通过其局麻作用而非全身作用减轻异丙酚注射痛
- Author:
Lin LIANG
;
Pinjie HUANG
;
Chenfang LUO
;
Gangjie LUO
- Publication Type:Journal Article
- Keywords:
Propofol;
Injection pain;
Lidocaine;
Verbal rating scales
- From:
The Journal of Practical Medicine
2015;(12):2017-2020
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of lidocaine injection in the alleviation of pains of propofol injection. Methods 430 patients, who underwent elective gastrointestinal endoscopy under general anesthesia , were randomly assigned into 3 groups: group A received 2 mL NS intravenous injection on the right dorsal hand;group B received 40 mg Lidocaine intravenous injection on the right dorsal hand and group C received 40 mg lidocaine intravenous injection on the left dorsal hand. All groups received 2 mg/kg Propofol intravenous injectionon the right dorsal hand at the rate of 20 mL/min. The injection pains were evaluated while the dosage reached 1/4 of the total (2 mg/kg). The left dosage of Propofol and 50 μg Fentanil were pumped after evaluation. Propofol dosage was added when needed. Mean arterial pressure (MAP) and heart rate (HR ) were recorded before Propofol injection and 1, 3, 5 minutes after Propofol injection. Results VRS comparisons: Tthe rate of pain incidence of group B was significantly lower than those of group A and C. MAP were declined dramatically at the time points of 1 minute, 3 minutes and 5 minutes after propofol injection, as compared to before propofol injection. The HR was declined dramatically 5 minutes after propofol injection. Conclusion Intravenous Lidocaine of 40 mgcould reduce Propofol-induced injection pain of the same vein. Local effect of Lidocaine but not its systemic function may play an important role in reducing Propofol-induced injection pain.
