The study on the relationship of the abnormal apoptosis of lupus nephritis pathology and disease ac-tivity
- VernacularTitle:狼疮肾炎细胞凋亡异常与病情活动的关系
- Author:
Ping CAO
;
Hong LIU
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Optosis
- From:
Journal of Chinese Physician
2015;(z1):54-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the abnormal apoptosis and lupus nephritis pathology and disease activity relationship.Methods Forty patients with LN renal biopsy tissue, cell apoptosis with TUNEL method and counting cell apoptosis index ( AI) , application of SLE activity score ( SLEDAI) 2000 judged the disease activity, and correlation analysis.Results All patients of renal tissue apoptosis detection were positive, apoptotic cells in the glomerulus and renal tubules were scattered distribution, SLEDAI was posi-tively correlated with the AI ( r =0.38, P =0.029).Conclusions Cell apoptosis and remove obstacles exist in Patients with LN, the more the number of apoptotic cells, the more active SLE disease.
