Tadalafil attenuates chronic allograft vasculopathy in rat

VernacularTitle:他达拉非延缓大鼠慢性移植血管硬化病变
Author: Ziqiang XU ; Pen XIA ; Jinjun WAN ; Hao JIN ; Yirong YANG
Publication Type:Journal Article
Keywords: Tadalafil; Graft Occlusion; Transplantation
From: The Journal of Practical Medicine 2015;(11):1755-1758
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of tadalafil on chronic allograft vasculopathy. Method The abdominal aorta transplantation was performed on Male Lewis or Brown-Norwai rats as donors and male Male Lewis rats as recipients. The recipients were divided into 3 groups: Group A (Lewis-Lewis)with no treatment ;Group B (BN-Lewis) with no treatment; Group C (BN-Lewis) received tadalafil treatment (0.5 mg/kg per day). The rats were sacrificed at 8 weeks post treatment. The grafted aortas were used for histology and Western blot assay. Plasma cGMP level was detected by ELISA assay. Results The aortas intimal in group C was significantly thinner than that in group B. PKG-Ⅰprotein expression in group C was significantly higher than that in group B. Expression of RhoA in group C was lower than that in group B. Conclusion Tadalafil has positive effect on chronic allograft vasculopathy.