Efficacy of statin in treatment of patients with chronic obstructive pulmonary disease at stable stage
10.3969/j.issn.1006-5725.2015.11.036
- VernacularTitle:他汀类药物在慢性阻塞性肺疾病稳定期患者中的作用
- Author:
Wei DONG
;
Ping KANG
;
Xiangzhu ZHONG
;
Lin TANG
;
Jianfang CHEN
;
Hongying CHENG
;
Weifen PENG
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
statin;
Pulmonary function;
C-reactive protein
- From:
The Journal of Practical Medicine
2015;(11):1835-1837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the therapeutic effects of statin in patients with chronic obstructive pulmonary disease (COPD) in stable period. Methods 83 patients with COPD in stable period were recruited and randomly divided into two groups, treatment group (n = 41) and control group (n = 42).The control group received conventional routine therapy, and treatment group was given rosuvastatin calcium 20 mg once per day on the basis of routine treatment. The levels of sera C-reactive protein (CRP), pulmonary function (FEV1、FEVl%pred), and COPD assessment test (CAT) were observed at the time points of 0 week and 12th week, 24th week and 48th week were compared between two groups. Results At 12th week after the treatment, sera CRP levels, FEV1, FEV1%pred and CAT scores in either control group or treatment group showed some extent of improvements as compared to those at the time point of 0 week, and there was statistical difference of sera CRP levels and CAT scores between two groups (P < 0.05). There was no statistical difference of FEV1, FEV1%pred between two groups (P > 0.05) .24th week and 48th week after the treatment; sera CRP levels, FEV, FEV1%pred and CAT scores in two groups all significantly improved and were statistical different between two groups (P < 0.05). Conclusion Statin can alleviate inflammatory reaction, improve pulmonary function and life quality of patients with COPD.
