Relationship between chromosomal aberrations of urine exfoliated cells and histological findings of bladder cancer
10.3969/j.issn.1006-5725.2015.12.008
- VernacularTitle:尿脱落细胞染色体畸变与膀胱癌组织学关系的研究
- Author:
Junwu RAN
;
Jun LV
;
Wei WANG
;
Qinsong ZENG
;
Xiaodong CHEN
;
Weilie HU
;
Wei WANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Fluorescence in situ hybridization;
Urine exfoliated cells;
Chromosomal aberrations
- From:
The Journal of Practical Medicine
2015;(12):1925-1928
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the relationship of pathological grade and stage of bladder cancer with common chromosomal aberrations of urine exfoliated cells by FISH. Methods A total of 99 urine samples were detected by FISH with probes of chromosomes 3,7,17 and 9p21 to collect pathological grade and stage information of bladder tumor tissues. Results (1) The aberrations of chromosome 3 and 17 had significant correlation with pathological grade and stage (P<0.05) but that of chromosome 7 had no correlation with pathological stage (P>0.05), but had correlation with grade (P < 0.05). The aberration of 9p21 had no correlations with pathological grade or stage (P > 0.05). (2)The polysomic chromosomal aberrations of chromosomes 3, 7 and 17 assessed correlated with high-grade and high-stage bladder carcinoma. The 9p21 deletion was found at a significant frequency in low-grade and low-stage lesions, when, 9p21 amplification was found at a significant frequency in high-grade and high-stage lesions. Conclusions Aberrations of the four chromosomes, especially polysomic chromosomal aberrations of the bladder cancer cases could present a possible trend toward greater chromosome increased with tumor grades and progressive stages of invasion.
