Correlation between the level of Ca2+/calmodulin-dependent protein kinases IV and essential hypertension in Shihezi community
10.3969/j.issn.1006-5725.2015.12.013
- VernacularTitle:石河子市社区高血压患者血清钙／钙调蛋白依赖性蛋白激酶Ⅳ水平的相关性
- Author:
Zhong WANG
;
Shaoze CHEN
;
Ruofei ZHAO
;
Jun YANG
;
Li WANG
;
Zhihong ZHAI
;
Hongqiang REN
;
Lihua ZHENG
- Publication Type:Journal Article
- Keywords:
Essential Hypertension;
Ca2+/calmodulin-dependent protein kinasea Ⅳ;
Community
- From:
The Journal of Practical Medicine
2015;(12):1942-1944
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the level of CaMKIV and essential hypertension (EH) in Shihezi community. Methods One hundred and forty-six patients with EH and 142 with normal blood pressure are enrolled from 15 communities in shihezi. We collected the clinical data, including blood pressure, body mass index, waist circumference, blood lipids. The serum level of CaMKIV was detected using an enzyme linked immunosorbent assay. Results The serum level of CaMKIV in the EH group was significantly lower than that in the normal blood pressure group (P < 0.05). The serum CaMKIV was negatively correlated with systolic BP and diastolic BP (r = -0.304, -0.452, all P < 0.05), with more obvious correlation with patients whose diastolic blood pressure was over 100 mmHg (r = -0.571, P < 0.05). Conclusions The serum level of CaMKIV is negatively correlated with EH, which is an independent factor of EH.
