Expression and effect of related factors of lymphangiogenesis in colorectal cancer
10.3760/cma.j.issn.1673-422X.2015.07.018
- VernacularTitle:淋巴管生成相关因子在结直肠癌中的表达和作用
- Author:
Yuemeng ZHANG
;
Shanshan SUN
;
Wenzhi LIU
;
Wencang GAO
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Endothelial growth factors;
Lymphangiogenesis
- From:
Journal of International Oncology
2015;(7):542-544
- CountryChina
- Language:Chinese
-
Abstract:
The lymphatic metastasis affects prognosis and survival of colorectal cancer seriously,and lymphangiogenesis plays an important role in the lymphatic metastasis. Many factors such as COX-2 and MMP-7 which are found in many researches recently can promote the expression of VEGF-C which can promote the lym-phangiogenesis by connecting with its receptor and activating the relevant signal pathway. At present,as these related factors of lymphangiogenesis are found in colorectal cancer,the process of lymphangiogenesis in colorec-tal cancer becomes more clear,but the exact mechanism of these factors needs to be researched in future.
