Effects ofZhenqi-Fuzhengcapsule combined with highly active antiretroviral therapy the Thl/Th2, Tcl/Tc2, and CD4+T lymphocytes in patients with advanced AIDS
10.3760/cma.j.issn.1673-4246.2015.07.005
- VernacularTitle:贞芪扶正胶囊联合高效抗逆转录病毒疗法对艾滋病患者Thl/Th2、Tcl/Tc2和CD4+ T淋巴细胞的影响
- Author:
Renfang CHEN
;
Yaping DAI
;
Qien YANG
;
Yuhong LU
;
Yiming JIANG
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
T-Lymphocyte subsets;
CD4-positive T-lymphocytes;
Th1 cells;
Th2 cells;
Antiretroviral therapy,highly active;
Zhenqi-Fuzhengcapsule
- From:
International Journal of Traditional Chinese Medicine
2015;(7):594-597
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects ofZhenqi-Fuzheng capsule combined with highly active antiretroviral therapy (HAART) the Thl/Th2, Tcl/Tc2, and CD4+ T lymphocytes in patients with advanced AIDS.Methods A total of 70 patients with advanced AIDS were randomly divided into a treatment group and a control group, with 35 patients in each group. The treatment group was treated withZhenqi-Fuzheng capsule combined with HAART, while the control group was treated with HAART only. The patients in both groups were treated for 24 weeks. The Thl, Th2, Tcl, Tc2 and CD4+ T lymphocytes in peripheral blood were detected by flow cytometer.Results After treatment, the ratios of Th1/Th2 (6.27 ± 0.70vs. 5.39 ± 0.64;P<0.05) and Tcl/Tc2 (10.70 ± 0.68vs. 10.16 ± 0.85;P<0.05) in the treatment group showed significantly higher than those in the control group. The CD4+T lymphocytes after the treatment in both groups showed significantly increased than that before the treatment (treatment group: 289.2 ± 101.5/mlvs. 121.1 ± 77.5/ml,P<0.01; control group: 231.6 ± 97.6/mlvs. 118.9 ± 76.2/ml,P<0.01). The CD4+T lymphocytes in the treatment group showed significantly increased than that in the control group after the treatment (P<0.05).ConclusionsZhenqi-Fuzhengcapsule combined with HAART may regulate the Thl/Th2 and Tcl/Tc2, and increase the CD4+ T lymphocytes in patients with advanced AIDS.
