The absorption and metabolism differences of intestine and liver for multicomponent licorice water extract
10.3760/cma.j.issn.1673-4246.2015.07.015
- VernacularTitle:甘草水提物多成分肝肠吸收代谢差异研究
- Author:
Lei ZHANG
;
Yanli PAN
;
Yang LIU
;
Mingmin TANG
;
Li WEI
;
Chengbo HOU
;
Xiao CHENG
;
Hao WANG
- Publication Type:Journal Article
- Keywords:
Licorice water extract;
Ultra performance liquid chromatography tandem mass spectrometry;
Absorption and metabolism differences;
In situ closed-loop
- From:
International Journal of Traditional Chinese Medicine
2015;(7):636-640
- CountryChina
- Language:Chinese
-
Abstract:
Objective This paper was to study the absorption and metabolism differences of intestine and liver for multicomponent licorice.Methods The components were identified with the UPLC-MS/MS. In situ closed-loop method was used to carry out the comparative experiments of absorption and metabolism differences between intestine and liver.Results 13 components were identified by UPLC-MS/MS. The absorption and metabolism results indicated some components in licorice water extract could be absorbed into blood and metabolism happened during this process. 14 metabolites were detected in the plasma sample. The hepatic metabolism results indicated many components could experience complex metabolism and more metabolites could be generated.Conclusions Liver was the major metabolism organ for licorice water extract and some components could be metabolized along with the absorption process in intestine. The absorption and metabolism differences between intestine and liver were significant.
