Inducible costimulatory molecule and its roles in tumor microenvironment
10.3760/cma.j.issn.1673-422X.2015.07.010
- VernacularTitle:可诱导共刺激分子及其在肿瘤中的作用
- Author:
Dongjuan WU
;
Dong HUA
- Publication Type:Journal Article
- Keywords:
Immunity;
Tumor microenvironment;
Inducible costimulatory molecule
- From:
Journal of International Oncology
2015;(7):516-518
- CountryChina
- Language:Chinese
-
Abstract:
Inducible costimulatory molecule(ICOS)is a member of the CD28 family,which can be expressed on the tumor tissues and immune cells in the tumor microenvironment. ICOS enhances its anti-tumor activity through participating in CD4 + T and CD8 + T cell immune response and enhancing the secretion of cyto-kines on the activated T cells and NK cells. While the curative effect of cytotoxic T lymphocyte-associated anti-gen-4(CTLA-4)monoclonal antibody is relevant with CD4 + T cells expressing ICOS,which suggesting ICOS may become a novel anti-tumor therapeutic target in the future.
