Expressions and roles of long non-coding RNA UCA1 in tumors
10.3760/cma.j.issn.1673-422X.2015.07.011
- VernacularTitle:长非编码 RNA UCA1在肿瘤中的表达及作用
- Author:
Yi ZHAO
;
Xingxing ZHANG
;
Min XU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Long non-coding RNA;
Urothelial carcinoma associated antigen 1
- From:
Journal of International Oncology
2015;(7):519-521
- CountryChina
- Language:Chinese
-
Abstract:
Urothelial carcinoma associated antigen 1(UCA1)is a highly bladder cancer-specific long non-coding RNA(lncRNA),and it does not have the function of encoding protein. UCA1 differentially expre-sses in various fetal tissues,but its expression is turned off in most adult tissues. It reactivates during tumori-genesis. Researches indicate that UCA1 may regulate cell proliferation,apoptosis,metastasis and chemoresis-tance of tumors,such as bladder cancer,breast cancer and hepatocellular cancer.
