Roles of transient receptor potential canonical channels in tumors

VernacularTitle:瞬时受体电位C在肿瘤中的作用
Author: Linjun WANG ; Dong HUA
Publication Type:Journal Article
Keywords: Neoplasms; Transient receptor potential canonical channel
From: Journal of International Oncology 2015;(7):522-524
CountryChina
Language:Chinese
Abstract: Transient receptor potential(TRP)channels as an important non-selective cation channels family mainly permeate Ca2 + ,Na + and other cations. TRPC channel is a subtribe of TRP family which regu-lates the second messenger of Ca2 + concentration and variety of protease activity,and which can directly or in-directly affect the biological behavior of cells. Recently,more and more evidences have certificated the TRPC channels affect the tumorigenesis and development,such as regulation of proliferation,differentiation,migra-tion,apoptosis and resistance of chemotherapeutic agents during cancer progression.