Research on the clinical efficacy of standard large trauma craniotomy for intracranial hematoma ;caused by severe traumatic brain injury
10.3969/j.issn.1005-6483.2015.06.007
- VernacularTitle:标准大骨瓣开颅手术对重型创伤性颅脑损伤所致颅内血肿的临床疗效研究
- Author:
Hongquan WANG
;
Shulan HUANG
- Publication Type:Journal Article
- Keywords:
traumatic brain injury;
intracranial hematoma;
neuron-specific enolase;
in-flammatory cytokines;
standard craniotomy bone
- From:
Journal of Clinical Surgery
2015;(6):420-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of standard large trauma craniotomy on neuron-specific enolase(NSE)inflammatory factors in patients withintracranial hematoma caused by severe trau-matic brain injury(sTBI).Methods A total of 64 cases of sTBI patients were randomly divided into con-ventional surgery group (conventional group)and standard large trauma craniotomy group (standard group),with 32 cases in each group.The postoperative Glasgow Outcome Scale(GOS)score,preoperative and postoperativeserum inflammatory factors(IL-8,IL-6,TNF-α,ICAM-1 ,and IL-1 0),NSE levels,and postoperative complications were compared.Results The GOS score of the standard group was signifi-cantly superior tothe conventional group(P <0.05);postoperativeIL-6,TNF-α,ICAM-1 ,and NSE levels in the conventional group were significantly reduced(P <0.05);postoperativeIL-8,IL-6,TNF-α,ICAM-1 ,and NSE levels were significantly reduced and IL-1 0 levelswassignificantly improvedin the standard group(P <0.05);there were3 cases of postoperative cerebrospinal fluid leakage and four cases of inci-sional hernia in the conventional group,and two cases of postoperative cerebrospinal fluid leakage and three cases of incisional hernia in the standard group;there were no significant differencesin the incidence of postoperative complications in both groups(P >0.05 ).Conclusion Inflammatory factors and NSE both playimportant roles in sTBI.Standard large trauma craniotomycan control these indicators effectively and reduce the severity of the patient's illness.
