Effect of gliclazide on the proliferation and differentiation in mouse osteoblastic-like cells MC3T3-E1
10.3760/cma.j.issn.1000-6699.2015.06.015
- VernacularTitle:格列齐特对小鼠成骨细胞样细胞 MC3T3-E1增殖及分化的影响
- Author:
Shuang JIN
;
Huijuan ZHANG
;
Juan ZHANG
;
Wei ZHANG
;
Haofeng ZHOU
- Publication Type:Journal Article
- Keywords:
Gliclazide;
MC3T3-E1 cells;
Proliferation;
Differentiation
- From:
Chinese Journal of Endocrinology and Metabolism
2015;(6):535-537
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] To investigate the effect of gliclazide on the proliferation and differentiation in MC3T3-E1 cells exposed to normal glucose concentration by applying CCK-8 and RT-PCR. Gliclazide improved the proliferation and stimulated COL-I, OPN and Runx2 mRNA expression in MC3T3-E1 cells, the best concentration of gliclazide was 20μmol/ L, the expression of COL-1 and OPN mRNA had a significant positive correlation with Runx2 binding activity.
