Clinical applications of long non-coding RNA detection in cancers
10.3760/cma.j.issn.1009-9158.2015.06.016
- VernacularTitle:长链非编码RNAs检测在肿瘤的临床应用
- Author:
Min YANG
;
Ning MA
;
Haitao FU
;
Renqian ZHONG
- Publication Type:Journal Article
- Keywords:
RNA,long noncoding;
Tumor markers,biological
- From:
Chinese Journal of Laboratory Medicine
2015;(6):424-427
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the discovery of thousands of long non-coding RNAs ( lncRNAs) has certainly changed human′s view of the complexity of mammalian genomes and transcriptome, as they play an important role in the regulation of transcription, post-transcription as well as epigenetic level, widely involved in various physiological process and diseases.Here this review summarized the lncRNAs associated with cancers, discussed the established methods used to detect and quantify lncRNAs, and evaluated the clinical application of lncRNAs as biomarker.
